Center for Beta Cell Therapy in Diabetes

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Title DOI
https://doi.org/10.1016/j.cell.2007.12.015 β Cells Can Be Generated from Endogenous Progenitors in Injured Adult Mouse Pancreas
https://doi.org/10.1016/j.cell.2009.05.035 The Ectopic Expression of Pax4 in the Mouse Pancreas Converts Progenitor Cells into α and Subsequently β Cells
https://doi.org/10.1016/j.devcel.2009.11.003 Pancreatic Exocrine Duct Cells Give Rise to Insulin-Producing β Cells during Embryogenesis but Not after Birth
https://doi.org/10.1016/s0014-5793(02)03110-1 Sustained activation of AMP‐activated protein kinase induces c‐Jun N‐terminal kinase activation and apoptosis in liver cells
https://doi.org/10.2337/db09-1486 Simultaneous Detection of Circulating Autoreactive CD8+ T-Cells Specific for Different Islet Cell–Associated Epitopes Using Combinatorial MHC Multimers
https://doi.org/10.2337/db07-0416 Screening for Insulitis in Adult Autoantibody-Positive Organ Donors
https://doi.org/10.1371/journal.pone.0002435 Cellular Islet Autoimmunity Associates with Clinical Outcome of Islet Cell Transplantation
https://doi.org/10.1073/pnas.0608141103 Correlation between β cell mass and glycemic control in type 1 diabetic recipients of islet cell graft
https://doi.org/10.2337/db09-1698 β-Cell Replication Is Increased in Donor Organs From Young Patients After Prolonged Life Support
https://doi.org/10.1097/tp.0000000000002217 Report of the Key Opinion Leaders Meeting on Stem Cell-derived Beta Cells
https://doi.org/10.1111/j.1600-6143.2008.02479.x Allograft-Specific Cytokine Profiles Associate with Clinical Outcome After Islet Cell Transplantation
https://doi.org/10.1111/dom.12257 Reanalysis of study of pancreatic effects of incretin therapy: methodological deficiencies
https://doi.org/10.1016/j.bcp.2004.04.003 Metformin-induced stimulation of AMP-activated protein kinase in β-cells impairs their glucose responsiveness and can lead to apoptosis
https://doi.org/10.2337/db09-0160 Differences in Baseline Lymphocyte Counts and Autoreactivity Are Associated With Differences in Outcome of Islet Cell Transplantation in Type 1 Diabetic Patients
https://doi.org/10.1038/sj.bjp.0707189 Methyl succinate antagonises biguanide‐induced AMPK‐activation and death of pancreatic β‐cells through restoration of mitochondrial electron transfer
https://doi.org/10.1007/s00125-016-4125-y Immunogenicity of human embryonic stem cell-derived beta cells
https://doi.org/10.1111/j.1463-1326.2008.00941.x Restoring a functional β‐cell mass in diabetes
https://doi.org/10.1016/j.semcdb.2010.07.007 Pancreatic beta-cells: From generation to regeneration
https://doi.org/10.1371/journal.pone.0043959 Beta Cell Count Instead of Beta Cell Mass to Assess and Localize Growth in Beta Cell Population following Pancreatic Duct Ligation in Mice
https://doi.org/10.1016/j.bcp.2008.02.019 Akt activation protects pancreatic beta cells from AMPK-mediated death through stimulation of mTOR
https://doi.org/10.1007/s00125-010-1721-0 Human islet cell implants in a nude rat model of diabetes survive better in omentum than in liver with a positive influence of beta cell number and purity
https://doi.org/10.1097/tp.0b013e31822ca79b Comparative Evaluation of Simple Indices of Graft Function After Islet Transplantation
https://doi.org/10.1038/s41467-020-19485-3 Tp63-expressing adult epithelial stem cells cross lineages boundaries revealing latent hairy skin competence
https://doi.org/10.1007/s11892-013-0399-3 Immune Monitoring of Islet and Pancreas Transplant Recipients
https://doi.org/10.1016/j.mce.2009.12.016 Reprogramming into pancreatic endocrine cells based on developmental cues
https://doi.org/10.1016/j.tem.2016.03.010 Boost for Alginate Encapsulation in Beta Cell Transplantation
https://doi.org/10.1016/j.bbrc.2003.11.013 Prolonged culture in low glucose induces apoptosis of rat pancreatic β-cells through induction of c-myc
https://doi.org/10.1371/journal.pone.0007266 Susceptibility of Pancreatic Beta Cells to Fatty Acids Is Regulated by LXR/PPARα-Dependent Stearoyl-Coenzyme A Desaturase
https://doi.org/10.1007/s00125-004-1426-3 Human pancreatic duct cells can produce tumour necrosis factor-α that damages neighbouring beta cells and activates dendritic cells
https://doi.org/10.2337/diabetes.54.12.3387 Growth and Functional Maturation of β-Cells in Implants of Endocrine Cells Purified From Prenatal Porcine Pancreas
https://doi.org/10.1007/s00125-008-1026-8 Glibenclamide activates translation in rat pancreatic beta cells through calcium-dependent mTOR, PKA and MEK signalling pathways
https://doi.org/10.1371/journal.pone.0193670 An analytical comparison of three immunoassay platforms for subpicomolar detection of protein biomarker GAD65
https://doi.org/10.1002/term.2329 CD99 as surface anchor for human islet endocrine cell purification
https://doi.org/10.1371/journal.pone.0085174 Glucose Regulates Rat Beta Cell Number through Age-Dependent Effects on Beta Cell Survival and Proliferation
https://doi.org/10.1007/s00125-003-1118-4 Formation of insulin-positive cells in implants of human pancreatic duct cell preparations from young donors
https://doi.org/10.3390/genes12010003 Oxidative Stress, Glutathione Metabolism, and Liver Regeneration Pathways Are Activated in Hereditary Tyrosinemia Type 1 Mice upon Short-Term Nitisinone Discontinuation
https://doi.org/10.1097/tp.0b013e3182977afc Predictive Factors of Allosensitization After Immunosuppressant Withdrawal in Recipients of Long-Term Cultured Islet Cell Grafts
https://doi.org/10.1152/ajpendo.00070.2016 Direct effect of glucocorticoids on glucose-activated adult rat β-cells increases their cell number and their functional mass for transplantation
https://doi.org/10.1111/j.1399-3089.2006.00328.x Xenotransplantation of purified pre‐natal porcine beta cells in mice normalizes diabetes when a short anti‐CD4–CD8 antibody treatment is combined with transient insulin injections
https://doi.org/10.1677/joe-10-0372 Interaction of glibenclamide and metformin at the level of translation in pancreatic cells
https://doi.org/10.3727/096368910x550242 Pdx1 - and Ngn3-Cre -Mediated PLAG1 Expression in the Pancreas Leads to Endocrine Hormone Imbalances That Affect Glucose Metabolism
https://doi.org/10.1097/01.tp.0000164143.22287.e3 Alloreactivity Against Repeated HLA Mismatches of Sequential Islet Grafts Transplanted in Non-Uremic Type 1 Diabetes Patients
https://doi.org/10.1016/j.humimm.2005.01.018 HLA Incompatibility and Immunogenicity of Human Pancreatic Islet Preparations Cocultured with Blood Cells of Healthy Donors
https://doi.org/10.5966/sctm.2015-0187 Concise Review: Markers for Assessing Human Stem Cell-Derived Implants as β-Cell Replacement in Type 1 Diabetes
https://doi.org/10.1111/ajt.16398 Formation of amyloid in encapsulated human pancreatic and human stem cell-generated beta cell implants
https://doi.org/10.1055/s-2006-949520 Adiponectin Expression is Paradoxically Increased in Gold-thioglucose-induced Obesity
https://doi.org/10.1016/s9999-9994(09)20391-6 The Ectopic Expression of Pax4 in the Mouse Pancreas Converts Progenitor Cells into α and Subsequently β Cells
https://doi.org/10.1111/j.1365-2249.2011.04605.x Immune responses against islet allografts during tapering of immunosuppression - A pilot study in 5 subjects
https://doi.org/10.3727/096368916x693437 Identification of Donor Origin and Condition of Transplanted Islets in Situ in the Liver of a Type 1 Diabetic Recipient
https://doi.org/10.1371/journal.pone.0212210 Glucocorticoids and checkpoint tyrosine kinase inhibitors stimulate rat pancreatic beta cell proliferation differentially
https://doi.org/10.1002/9780470697405.ch3 The β Cell Population in Type 1 Diabetes
Islet Beta Cell transplantation in Type1 diabetic patients with early chronic complications.
https://doi.org/10.1016/s9999-9994(09)20442-9 The Ectopic Expression of Pax4 in the Mouse Pancreas Converts Progenitor Cells into α and Subsequently β Cells
https://doi.org/10.1080/16089677.2023.2198348 Initiating or switching to IDegAsp in a real-world South African population with type 2 diabetes – a cohort analysis from the ARISE study