VIB-VUB Laboratory Myeloid Cell Immunology

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Title DOI
https://doi.org/10.1016/j.immuni.2014.06.008 Macrophage Activation and Polarization: Nomenclature and Experimental Guidelines
https://doi.org/10.1038/s41593-019-0393-4 A single-cell atlas of mouse brain macrophages reveals unique transcriptional identities shaped by ontogeny and tissue environment
https://doi.org/10.1038/ncomms10321 Bone marrow-derived monocytes give rise to self-renewing and fully differentiated Kupffer cells
https://doi.org/10.1038/s41593-020-00789-y Single-cell profiling of myeloid cells in glioblastoma across species and disease stage reveals macrophage competition and specialization
https://doi.org/10.1016/j.immuni.2019.08.017 Stellate Cells, Hepatocytes, and Endothelial Cells Imprint the Kupffer Cell Identity on Monocytes Colonizing the Liver Macrophage Niche
https://doi.org/10.1016/j.ccr.2013.11.007 Impeding Macrophage Entry into Hypoxic Tumor Areas by Sema3A/Nrp1 Signaling Blockade Inhibits Angiogenesis and Restores Antitumor Immunity
https://doi.org/10.1016/j.immuni.2014.09.014 Molecular Profiling Reveals a Tumor-Promoting Phenotype of Monocytes and Macrophages in Human Cancer Progression
https://doi.org/10.3389/fimmu.2017.00289 Macrophage Metabolism As Therapeutic Target for Cancer, Atherosclerosis, and Obesity
https://doi.org/10.1016/j.immuni.2018.07.004 The Transcription Factor ZEB2 Is Required to Maintain the Tissue-Specific Identities of Macrophages
https://doi.org/10.1016/j.cmet.2019.07.015 Podoplanin-Expressing Macrophages Promote Lymphangiogenesis and Lymphoinvasion in Breast Cancer
https://doi.org/10.1158/0008-5472.can-15-0869 M-CSF and GM-CSF Receptor Signaling Differentially Regulate Monocyte Maturation and Macrophage Polarization in the Tumor Microenvironment
https://doi.org/10.3389/fimmu.2014.00489 Functional Relationship between Tumor-Associated Macrophages and Macrophage Colony-Stimulating Factor as Contributors to Cancer Progression
https://doi.org/10.1016/j.immuni.2020.09.018 Interleukin-10 Prevents Pathological Microglia Hyperactivation following Peripheral Endotoxin Challenge
https://doi.org/10.3389/fimmu.2014.00127 Mechanisms Driving Macrophage Diversity and Specialization in Distinct Tumor Microenvironments and Parallelisms with Other Tissues
https://doi.org/10.1016/j.immuni.2020.11.007 A Binary Cre Transgenic Approach Dissects Microglia and CNS Border-Associated Macrophages
https://doi.org/10.1016/j.cellimm.2018.02.008 Myeloid cell heterogeneity in cancer: not a single cell alike
https://doi.org/10.1016/j.immuni.2022.09.005 Differential plasticity and fate of brain-resident and recruited macrophages during the onset and resolution of neuroinflammation
https://doi.org/10.1186/1742-2094-9-176 Acute injury in the peripheral nervous system triggers an alternative macrophage response
https://doi.org/10.2967/jnumed.115.156828 PET Imaging of Macrophage Mannose Receptor–Expressing Macrophages in Tumor Stroma Using 18F-Radiolabeled Camelid Single-Domain Antibody Fragments
https://doi.org/10.1016/j.cell.2023.01.017 The choroid plexus links innate immunity to CSF dysregulation in hydrocephalus
https://doi.org/10.1016/j.bbcan.2015.06.009 Tissue-resident versus monocyte-derived macrophages in the tumor microenvironment
https://doi.org/10.7150/thno.34941 Theranostics in immuno-oncology using nanobody derivatives
https://doi.org/10.1189/jlb.0911453 Pivotal Advance: Arginase-1-independent polyamine production stimulates the expression of IL-4-induced alternatively activated macrophage markers while inhibiting LPS-induced expression of inflammatory genes
https://doi.org/10.1016/j.celrep.2021.110171 Macrophages are metabolically heterogeneous within the tumor microenvironment
https://doi.org/10.7150/thno.24762 Noninvasive imaging of the PD-1:PD-L1 immune checkpoint: Embracing nuclear medicine for the benefit of personalized immunotherapy
https://doi.org/10.1002/eji.201343349 Tumor‐induced myeloid‐derived suppressor cell subsets exert either inhibitory or stimulatory effects on distinct CD8+T‐cell activation events
https://doi.org/10.3389/fonc.2014.00349 Myeloid-Derived Suppressor Cells as Therapeutic Target in Hematological Malignancies
https://doi.org/10.3389/fimmu.2016.00233 Immune Evasion Strategies of Trypanosoma brucei within the Mammalian Host: Progression to Pathogenicity
https://doi.org/10.7150/thno.20094 Al18F-Labeling Of Heat-Sensitive Biomolecules for Positron Emission Tomography Imaging
https://doi.org/10.1002/advs.202004574 Targeted Repolarization of Tumor‐Associated Macrophages via Imidazoquinoline‐Linked Nanobodies
https://doi.org/10.1186/s40478-021-01204-8 CSF1R inhibition rescues tau pathology and neurodegeneration in an A/T/N model with combined AD pathologies, while preserving plaque associated microglia
https://doi.org/10.1186/s12934-014-0156-6 Delivery of a functional anti-trypanosome Nanobody in different tsetse fly tissues via a bacterial symbiont, Sodalis glossinidius
https://doi.org/10.1186/s12943-025-02270-5 Nanobodies targeting the tumor microenvironment and their formulation as nanomedicines
https://doi.org/10.1158/0008-5472.can-19-3360 Pharmacologic Activation of LXR Alters the Expression Profile of Tumor-Associated Macrophages and the Abundance of Regulatory T Cells in the Tumor Microenvironment
https://doi.org/10.1038/s41596-022-00716-4 Single-cell RNA and protein profiling of immune cells from the mouse brain and its border tissues
https://doi.org/10.1038/s41408-023-00962-z Targeting S100A9 protein affects mTOR-ER stress signaling and increases venetoclax sensitivity in Acute Myeloid Leukemia
https://doi.org/10.1002/hep.1840210130 Structure and dynamics of the fenestrae-associated cytoskeleton of rat liver sinusoidal endothelial cells
https://doi.org/10.2967/jnumed.112.111781 SPECT Imaging of Joint Inflammation with Nanobodies Targeting the Macrophage Mannose Receptor in a Mouse Model for Rheumatoid Arthritis
https://doi.org/10.4161/onci.21566 Instruction of myeloid cells by the tumor microenvironment: Open questions on the dynamics and plasticity of different tumor-associated myeloid cell populations
https://doi.org/10.1128/jvi.02500-16 Hierarchical and Redundant Roles of Activating FcγRs in Protection against Influenza Disease by M2e-Specific IgG1 and IgG2a Antibodies
https://doi.org/10.1016/j.nbt.2012.09.002 Development of VEGFR2-specific Nanobody Pseudomonas exotoxin A conjugated to provide efficient inhibition of tumor cell growth
https://doi.org/10.1111/jam.12447 Antibacterial activities of coagulase-negative staphylococci from bovine teat apex skin and their inhibitory effect on mastitis-related pathogens
https://doi.org/10.1038/leu.2012.113 Multiple myeloma induces the immunosuppressive capacity of distinct myeloid-derived suppressor cell subpopulations in the bone marrow
https://doi.org/10.1186/1475-2859-11-23 Expression and extracellular release of a functional anti-trypanosome Nanobody® in Sodalis glossinidius, a bacterial symbiont of the tsetse fly
https://doi.org/10.18632/oncotarget.3300 Multiple myeloma induces Mcl-1 expression and survival of myeloid-derived suppressor cells
https://doi.org/10.1016/j.cellimm.2018.03.010 The role of hepatic macrophages in liver metastasis
https://doi.org/10.2967/jnumed.113.130617 Molecular Imaging with Macrophage CRIg-Targeting Nanobodies for Early and Preclinical Diagnosis in a Mouse Model of Rheumatoid Arthritis
https://doi.org/10.1371/journal.pone.0045399 In Vivo Inhibition of c-MYC in Myeloid Cells Impairs Tumor-Associated Macrophage Maturation and Pro-Tumoral Activities
https://doi.org/10.1371/journal.ppat.1003731 A Trypanosoma brucei Kinesin Heavy Chain Promotes Parasite Growth by Triggering Host Arginase Activity
https://doi.org/10.1093/molbev/msv077 Paternal Transmission of a Secondary Symbiont during Mating in the Viviparous Tsetse Fly
https://doi.org/10.1371/journal.ppat.1004964 NK-, NKT- and CD8-Derived IFNγ Drives Myeloid Cell Activation and Erythrophagocytosis, Resulting in Trypanosomosis-Associated Acute Anemia
https://doi.org/10.1371/journal.pgen.1003662 Origin and Functional Diversification of an Amphibian Defense Peptide Arsenal
https://doi.org/10.1016/j.canlet.2018.11.002 Myeloid-derived suppressor cells induce multiple myeloma cell survival by activating the AMPK pathway
https://doi.org/10.1002/eji.201948162 Identifying the variables that drive tamoxifen‐independent CreERT2 recombination: Implications for microglial fate mapping and gene deletions
https://doi.org/10.1371/journal.ppat.1004873 Ly6C- Monocytes Regulate Parasite-Induced Liver Inflammation by Inducing the Differentiation of Pathogenic Ly6C+ Monocytes into Macrophages
https://doi.org/10.1016/j.imbio.2016.10.006 The non-mammalian MIF superfamily
https://doi.org/10.1002/eji.201445013 Macrophage dynamics are regulated by local macrophage proliferation and monocyte recruitment in injured pancreas
https://doi.org/10.1016/j.imbio.2013.07.004 The role of monocytes in the development of Tuberculosis-associated Immune Reconstitution Inflammatory Syndrome
https://doi.org/10.1016/j.imbio.2013.07.003 Modulation of CD8+ T-cell activation events by monocytic and granulocytic myeloid-derived suppressor cells
https://doi.org/10.4049/jimmunol.1402431 DUSP3 Genetic Deletion Confers M2-like Macrophage–Dependent Tolerance to Septic Shock
https://doi.org/10.5966/sctm.2014-0272 Concise Review: Macrophages: Versatile Gatekeepers During Pancreatic β-Cell Development, Injury, and Regeneration
https://doi.org/10.1097/qad.0b013e328361648b Modulation of the complement system in monocytes contributes to tuberculosis-associated immune reconstitution inflammatory syndrome
https://doi.org/10.1016/j.bbagen.2019.129506 Dehydrin ERD14 activates glutathione transferase Phi9 in Arabidopsis thaliana under osmotic stress
https://doi.org/10.1038/srep12599 E-cadherin expression in macrophages dampens their inflammatory responsiveness in vitro, but does not modulate M2-regulated pathologies in vivo
https://doi.org/10.1096/fj.201701189r Novel half‐life extended anti‐MIF nanobodies protect against endotoxic shock
https://doi.org/10.1016/j.bbadis.2016.02.007 Involvement of connexin43 in acetaminophen-induced liver injury
https://doi.org/10.1016/j.pt.2014.08.006 African trypanosome control in the insect vector and mammalian host
https://doi.org/10.1038/s41417-017-0002-1 Development of an adenovirus vector vaccine platform for targeting dendritic cells
https://doi.org/10.1128/jvi.01498-13 Targeting of Human Antigen-Presenting Cell Subsets
https://doi.org/10.4161/onci.27561 Hypoxia and tumor-associated macrophages
https://doi.org/10.1002/eji.202250024 A few good reasons to use nanobodies for cancer treatment
https://doi.org/10.1016/j.imbio.2014.09.018 Monitoring liver macrophages using nanobodies targeting Vsig4: Concanavalin A induced acute hepatitis as paradigm
https://doi.org/10.1016/j.imbio.2016.11.008 Structural evaluation of a nanobody targeting complement receptor Vsig4 and its cross reactivity
https://doi.org/10.1016/j.jconrel.2019.10.024 Stromal-targeting radioimmunotherapy mitigates the progression of therapy-resistant tumors
https://doi.org/10.3390/ijms21010310 Identification of Nanobodies against the Acute Myeloid Leukemia Marker CD33
https://doi.org/10.1002/glia.23875 Tightening the retinal glia limitans attenuates neuroinflammation after optic nerve injury
https://doi.org/10.7150/thno.77560 Size-advantage of monovalent nanobodies against the macrophage mannose receptor for deep tumor penetration and tumor-associated macrophage targeting
https://doi.org/10.1016/j.jhep.2024.07.007 Infection history imprints prolonged changes to the epigenome, transcriptome and function of Kupffer cells
https://doi.org/10.1016/j.addr.2022.114239 Imaging and therapeutic targeting of the tumor immune microenvironment with biologics
https://doi.org/10.1186/s40478-023-01580-3 Immune stimulation recruits a subset of pro-regenerative macrophages to the retina that promotes axonal regrowth of injured neurons
https://doi.org/10.1016/j.cellimm.2021.104296 Monocytic myeloid-derived suppressor cells home to tumor-draining lymph nodes via CCR2 and locally modulate the immune response
https://doi.org/10.1186/s13073-025-01511-y Epigenomic preconditioning of peripheral monocytes determines their transcriptional response to the tumor microenvironment
https://doi.org/10.1016/j.cej.2024.156200 Quantitative assessment of the 3D pore space and microglobule clustering network to understand chromatographic transport phenomena in polymeric monolithic columns
https://doi.org/10.1158/0008-5472.can-24-3095 Depleting IL1R2+ Tumor-Infiltrating Regulatory T Cells with an ADCC-Prone Nanobody Construct Boosts the Efficacy of Anti–PD-1 Immunotherapy
https://doi.org/10.1371/journal.pntd.0003561 Development of a pHrodo-Based Assay for the Assessment of In Vitro and In Vivo Erythrophagocytosis during Experimental Trypanosomosis
https://doi.org/10.1111/j.1365-3083.2012.02689.x Claudin‐1, Claudin‐2 and Claudin‐11 Genes Differentially Associate with Distinct Types of Anti‐inflammatory Macrophages In vitro and with Parasite‐ and Tumour‐elicited Macrophages In vivo
https://doi.org/10.1002/eji.201243168 E‐cadherin: From epithelial glue to immunological regulator
https://doi.org/10.1016/0270-9139(95)90427-1 Structure and dynamics of the fenestrae-associated cytoskeleton of rat liver sinusoidal endothelial cells*1
https://doi.org/10.18632/oncotarget.1680 Immunogenicity of targeted lentivectors
https://doi.org/10.1186/1475-2840-7-26 Effect of streptozotocin-induced diabetes on myocardial blood flow reserve assessed by myocardial contrast echocardiography in rats.
https://doi.org/10.1007/s11307-016-0976-3 Molecular Imaging with Kupffer Cell-Targeting Nanobodies for Diagnosis and Prognosis in Mouse Models of Liver Pathogenesis
https://doi.org/10.1016/j.ejphar.2013.01.026 [3H]IVDE77, a novel radioligand with high affinity and selectivity for the insulin-regulated aminopeptidase
https://doi.org/10.1371/journal.pone.0146704 The Possible Role of Staphylococcus epidermidis LPxTG Surface Protein SesC in Biofilm Formation
https://doi.org/10.1002/path.4112 Contribution of myeloid cell subsets to liver fibrosis in parasite infection
https://doi.org/10.1016/j.jconrel.2019.02.023 Single-domain antibody fusion proteins can target and shuttle functional proteins into macrophage mannose receptor expressing macrophages
https://doi.org/10.1371/journal.pntd.0001902 Affinity Is an Important Determinant of the Anti-Trypanosome Activity of Nanobodies
https://doi.org/10.1002/eji.201142331 The CD20 homolog Ms4a8a integrates pro‐ and anti‐inflammatory signals in novel M2‐like macrophages and is expressed in parasite infection
https://doi.org/10.1177/1470320313507621 Presence and regulation of insulin-regulated aminopeptidase in mouse macrophages
https://doi.org/10.1002/eji.201545559 The transduction pattern of IL‐12‐encoding lentiviral vectors shapes the immunological outcome
https://doi.org/10.1002/ijc.33334 Myeloid tumor necrosis factor and heme oxygenase‐1 regulate the progression of colorectal liver metastases during hepatic ischemia‐reperfusion